AZD8055

• Catalog No.: A808130
• CAS Number: 1009298-09-2
• M. F.: C25H31N5O4
• M. W.: 465.54474

SYNONYMS

• IUPAC name: (5-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
• IUPAC Traditional name: (5-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
• Synonyms: AZD 8055; 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]- 2-methoxyphenyl]methanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol

DATABASE IDS

• CAS Number: 1009298-09-2

DETAILS

Description (English)

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream protein

REFERENCES

• Chresta, C.M. et al.: Cancer Res., 70, 288 (2010)
• Sini, P. et al. Autophagy., 6 (2010)
• Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2010)