Atractyloside Disodium Salt Discontinued

• Catalog No.: A794530
• CAS Number: 100938-11-2
• M. F.: C30H44Na2O16S2
• M. W.: 770.7703
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: disodium (2R,3R,4R,5R,6R)-6-{[(1R,4R,5R,7R,9R,10S,13R,15S)-5-carboxy-15-hydroxy-9-methyl-14-methylidenetetracyclo[11.2.1.0^1,^1^0.0^4,^9]hexadecan-7-yl]oxy}-2-(hydroxymethyl)-5-[(3-methylbutanoyl)oxy]-4-(sulfonatooxy)oxan-3-yl sulfate
• IUPAC Traditional name: disodium (2R,3R,4R,5R,6R)-6-{[(1R,4R,5R,7R,9R,10S,13R,15S)-5-carboxy-15-hydroxy-9-methyl-14-methylidenetetracyclo[11.2.1.0^1,^1^0.0^4,^9]hexadecan-7-yl]oxy}-2-(hydroxymethyl)-5-[(3-methylbutanoyl)oxy]-4-(sulfonatooxy)oxan-3-yl sulfate
• Synonyms: Atractylin Sodium Salt; Sodium Atractylate; Atractylic Acid Disodium Salt; (2β,4α,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic Acid Disodium Salt

DATABASE IDS

• CAS Number: 100938-11-2

PROPERTIES

• Apperance: White Solid
• Melting Point: 218-220°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies o

REFERENCES

• Qin, Z.H. et al.: J. Biol. Chem., 276, 8079 (2001)
• Chang, N.S. et al.: J. Biol. Chem., 276, 3361 (2001)
• Ziegler, M. et al.: J. Biol. Chem., 268, 25320 (2001)
• Marzo, I. et al.: Science, 281, 2027 (2001)
• Vieira, H.L. et al.: Cell Death Differ., 7, 1146