Astemizole-d3

• Catalog No.: A790032
• CAS Number: 1189961-39-4
• M. F.: C28H31FN4O
• M. W.: 458.5703432
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 1-[(4-fluorophenyl)methyl]-N-(1-{2-[4-(^2H₃)methoxyphenyl]ethyl}piperidin-4-yl)-1H-1,3-benzodiazol-2-amine
• IUPAC Traditional name: 1-[(4-fluorophenyl)methyl]-N-(1-{2-[4-(^2H₃)methoxyphenyl]ethyl}piperidin-4-yl)-1,3-benzodiazol-2-amine
• Synonyms: Hismanal-d3; R 43512-d3; Waruzol-d3; Paralergin-d3; R 42512-d3; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxy-d3-phenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan-d3; Histamen-d3; Retolen-d3

DATABASE IDS

• CAS Number: 1189961-39-4

PROPERTIES

• Apperance: White Solid
• Melting Point: 145-150°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

Labelled Astemizole. Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.

REFERENCES

• Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981)
• Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1981)
• Richards, D.M., et al.: Drugs, 28, 38 (1981)
• Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1981)
• Ishikawa, M., et al.: Biol.