Artemether Tetrahydrofuran Acetate

• Catalog No.: A777415
• CAS Number: 181528-64-3
• M. F.: C16H26O5
• M. W.: 298.37464

SYNONYMS

• IUPAC name: (1R,5S,6R,9S,10R,11R,13R)-11-methoxy-6,10-dimethyl-2,12-dioxatricyclo[7.4.0.0^1,^5]tridecan-13-yl acetate
• IUPAC Traditional name: (1R,5S,6R,9S,10R,11R,13R)-11-methoxy-6,10-dimethyl-2,12-dioxatricyclo[7.4.0.0^1,^5]tridecan-13-yl acetate
• Synonyms: (3aS,4R,6aS,7R,8S,10R,10aR)-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol 10-Acetate,; [3aS-(3aα,4α,6aα,7β,8β,10α,10aS*)]-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol Acetate

DATABASE IDS

• CAS Number: 181528-64-3

DETAILS

Description (English)

A metabolite of Artemether (A777400) and derivative of the antimalarial drug Artemisinin (A777500). Studies suggest that it may display neurotoxicity in animals due to its interaction with iron.

REFERENCES

• Smith, S.L. et al.: Neurotoxicology, 19, 557 (1998)
• Blum, W. et al.: J. Chrom. B Biomed. Sci. Appl., 710, 101 (1998)