Aprepitant-13C2,d2 (Major)

• Catalog No.: A729802
• M. F.: C23H21F7N4O3
• M. W.: 536.41197208
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 3-{[(2R,3S)-2-{1-[3,5-bis(trifluoromethyl)phenyl](1,2-^2H₂)ethoxy}-3-(4-fluorophenyl)morpholin-4-yl](^1^3C)methyl}-4,5-dihydro(3-^1^3C)-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: 5-{[(2R,3S)-2-{1-[3,5-bis(trifluoromethyl)phenyl](1,2-^2H₂)ethoxy}-3-(4-fluorophenyl)morpholin-4-yl](^1^3C)methyl}-2,4-dihydro(5-^1^3C)-1,2,4-triazol-3-one
• Synonyms: Emend-13C2,d2; MK-0869-13C2,d2; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one-13C2,d2

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 244-246°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitan

REFERENCES

• Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (1998)
• Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)
• Campos, D., et al.: J. Clin. Oncol., 19, 1759 (1998)
• Van Belle, S., et al.: Cancer, 94, 3032 (1998)