Aprepitant

• Catalog No.: A729800
• CAS Number: 170729-80-3
• M. F.: C23H21F7N4O3
• M. W.: 534.4266624
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: aprepitant
• Synonyms: MK 869; Emend; ONO 7436; L 754030; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; MK 0869

DATABASE IDS

• CAS Number: 170729-80-3

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 244-246°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E

REFERENCES

• Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)
• Campos, D., et al.: J. Clin. Oncol., 19, 1759 (1998)
• Van Belle, S., et al.: Cancer, 94, 3032 (1998)
• Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (1998)