(R,R,R)-Aprepitant

• Catalog No.: A729785
• CAS Number: 1148113-53-4
• M. F.: C23H21F7N4O3
• M. W.: 534.4266624

SYNONYMS

• IUPAC name: 3-{[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: 5-{[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-1,2,4-triazol-3-one
• Synonyms: 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

DATABASE IDS

• CAS Number: 1148113-53-4

DETAILS

Description (English)

The (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant.

REFERENCES

• Chawla, S., et al.: Cancer, 97, 2290 (2003)
• Huskey, S., et al.: Drug Metab. Dispos., 31, 785 (2003)
• Warr, D., et al.: Eur. J. Cancer, 41, 1278 (2003)