Apatinib Hydrochloride

• Catalog No.: A726150
• CAS Number: 1218779-89-5
• M. F.: C34H49N5O6
• M. W.: 623.78276

SYNONYMS

• IUPAC name: (3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)-tetradecahydro-1H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• IUPAC Traditional name: (3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-3-(6-oxooctyl)-decahydro-2H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• Synonyms: YN968D1 Hydrochloride; N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

DATABASE IDS

• CAS Number: 1218779-89-5

DETAILS

Description (English)

Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration an

REFERENCES

• Mi, Y. et al.: Cancer Res., 70, 7981 (2010)
• Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2010)
• Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2010)