Atorvastatin-d5 Lactone

• Catalog No.: A791782
• M. F.: C33H33FN2O4
• M. W.: 540.6245232
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-4-(^2H₅)phenyl-N-phenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide
• IUPAC Traditional name: 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-2-isopropyl-4-(^2H₅)phenyl-N-phenylpyrrole-3-carboxamide
• Synonyms: Atorvastatin-d5 δ-Lactone; 5-(4-Fluorophenyl)-2-(1-methylethyl)-N-phenyl-(4-phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide

PROPERTIES

• Apperance: Light Yellow Solid
• Melting Point: 98-100°C
• Solubility: DMF
• Solubility: DMSO
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Labelled Atorvastatin intermediate as inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.

REFERENCES

• Boyd, R., et al.: J. Clin. Pharmacol., 40, 91, (2000)
• Bogman, K., et al.: Br. J. Pharmacol., 132, 1183 (2000)
• Backman, J., et al.: Clin. Pharmacol. Ther., 72, 685 (2000)
• Kalvass, J., et al.: Drug Metab. Dispos., 35, 455 (2000)