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6-ANILINO-5,8-QUINOLINEDIONE_Molecular_structure_CAS_91300-60-6)
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6-ANILINO-5,8-QUINOLINEDIONE

Catalog No. A664500 Name Toronto Research Chemicals
CAS Number 91300-60-6 Website http://www.trc-canada.com
M. F. C15H10N2O2 Telephone +1 (416) 665-9696
M. W. 250.2521 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 91023

SYNONYMS

IUPAC name
6-(phenylamino)-5,8-dihydroquinoline-5,8-dione
IUPAC Traditional name
6-(phenylamino)quinoline-5,8-dione
Synonyms
6-Anilinoquinoline-5,8-quinone
6-(Phenylamino)-5,8-quinolinedione
5,8-Dihydro-5,8-dioxo-6-(phenylamino)quinoline
LY 83583

DATABASE IDS

CAS Number 91300-60-6

PROPERTIES

Certificate of Analysis Download
Apperance Red-Brown Solid
Melting Point 184-185°C
Solubility Dichloromethane
MSDS Link Download

DETAILS

Description (English)
Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.

REFERENCES

  • Macleod, K.M., et al.: Mol. Pharmacol., 32, 59 (1987)
  • Mulsch, A. J.: J. Pharmacol. Exp. Ther., 247, 283 (1987)
  • Mulsch, A., et al.: Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 119 (1987)
  • Light, D.B., et al.: Science, 243, 383 (1987)
  • Beasley, D., et al