Anhydro Vinblastine-d3 Disulfate Salt

• Catalog No.: A659752
• M. F.: C46H56N4O8
• M. W.: 792.95884
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: methyl (1R,10S,11R,12R,19S)-11-(acetyloxy)-12-ethyl-4-[(13S,15R)-17-ethyl-13-[(^2H₃)methoxycarbonyl]-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9,16-pentaen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• IUPAC Traditional name: methyl (1R,10S,11R,12R,19S)-11-(acetyloxy)-12-ethyl-4-[(13S,15R)-17-ethyl-13-[(^2H₃)methoxycarbonyl]-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9,16-pentaen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• Synonyms: (+)-Anhydrovinblastine-d3 Disulfate Salt; 3',4'-Didehydroisoleurosine-d3 Disulfate Salt; 3',4'-Didehydro-4'-deoxyvincaleukoblastine-d3 Disulfate Salt; 3',4'-Dehydroisoleurosine-d3 Disulfate Salt; Anhydrovincaleukoblastine-d3 Disulfate Salt; 3',4'-Anhydrovinblastine-d3 Disulfate Salt; 3',4'-Dehydrovinblastine-d3 Disulfate Salt; F 81097-d3 Disulfate Salt

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 230-233°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Anhydrovinblastine showed significant cytotoxic potential against a panel of human cancer cell lines and significant activity against the human H460 non-small cell lung carcinoma tumor xenograph in mice.

REFERENCES

• Koiso, Y., et al.: J. Antibiot., 51, 418 (1998)
• Olver, I., et al.: Eur. J. Cancer, 43, 1829 (1998)
• Shao, Y., et al.: Bioorg. Med. Chem., 15, 5061 (2007).