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Amonafide-d6
Catalog No.	A634207	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C16H17N3O2	Telephone	+1 (416) 665-9696
M. W.	283.32508	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 160567

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SYNONYMS

IUPAC name

11-amino-3-{2-[bis(²H₃)methylamino]ethyl}-3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione

IUPAC Traditional name

11-amino-3-{2-[bis(²H₃)methylamino]ethyl}-3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione

Synonyms

5-Amino-2-[2-(dimethylamino-d6)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

NCI 308847-d6

MADE-FA 142-d6

FA 142-d6

M-FA 142-d6

NSC 308847-d6

Nafidimide-d6

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

Labelled Amonafide. It is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent.

REFERENCES

Hsiang, Y., et al.: Mol. Pharmacol., 36, 371 (1989)
Costanza, M., et al.: Clin. Cancer Res., 1, 699 (1989)
Innocenti, F., et al.: Drug Metab. Dispos., 29, 596 (1989)
Brana, M., et al.: J. Med. Chem., 47, 1391 (1989)