(R)-Amlodipine Hemi-dibenzoyl-L-tartrate

• Catalog No.: A633505
• M. F.: C38H39ClN2O13
• M. W.: 767.17486

SYNONYMS

• IUPAC name: (2R,3R)-2,3-bis(benzoyloxy)butanedioic acid 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: (2R,3R)-2,3-bis(benzoyloxy)butanedioic acid; (R)-amlodipine
• Synonyms: (R)-(+)-Amlodipine Hemi-dibenzoyl-L-tartrate; (+)-Amlodipine Hemi-dibenzoyl-L-tartrate; (4R)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester Hemi-dibenzoyl-L-tartrate; d-Amlodipine Hemi-dibenzoyl-L-tartrate

PROPERTIES

• Apperance: Off-White Solid
• Solubility: Methanol

DETAILS

Description (English)

(R)-Enantiomer of Amlodipine. A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

REFERENCES

• Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986)
• Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1986)
• Haria, M., et al.: Drugs, 50, 560 (1986)