9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate

• Catalog No.: A629700
• CAS Number: 1684-40-8
• M. F.: C13H15ClN2
• M. W.: 234.7246
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1,2,3,4-tetrahydroacridin-9-amine hydrochloride
• IUPAC Traditional name: tacrine hydrochloride
• Synonyms: 1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate; Tacrine Hydrochloride Dihydrate; Tenakrin Dihydrate; THA Dihydrate; Hydroaminacrine Dihydrate; Romotal Dihydrate

DATABASE IDS

• CAS Number: 1684-40-8

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 284-286°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and

REFERENCES

• Harper, J., et al.: Chem. Biol., 4, 119 ( 1997), Kirkitadze, M., et al.: J. Mol. Biol., 312, 1103 (2001)
• Zhuang, Z., et al.: J. Med. Chem., 44, 1905 (2001)
• Necula, M.J., et al.: Biol. Chem., 282, 10311 (2001)