(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

• Catalog No.: A611500
• CAS Number: 74341-63-2
• M. F.: C7H10N2O4
• M. W.: 186.1653
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid
• IUPAC Traditional name: AMPA
• Synonyms: AMPA; D,L-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid; γ-Amino-3-hydroxy-5-methylisoxazole-4-propionic Αcid

DATABASE IDS

• CAS Number: 74341-63-2

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: >200°C (dec.)
• Solubility: Water
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A potent and selective agonist of the putative, excitatory neurotransmitter L-glutamic acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists.

REFERENCES

• Krogsgaard-Larsen, et al.: Nature, 284, 64 (1980)
• Honore, T., et al.: J. Neurochem., 38, 173 (1980)
• MacDonald, J.F., et al.: Science, 253, 1132 (1991)