N-(2-Aminoethyl) Cyclopamine

• Catalog No.: A608925
• CAS Number: 334616-31-8
• M. F.: C29H46N2O2
• M. W.: 454.68774
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-4'-(2-aminoethyl)-3',6',10,11b-tetramethyl-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-3-ol
• IUPAC Traditional name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-4'-(2-aminoethyl)-3',6',10,11b-tetramethyl-2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a-hexadecahydro-1H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-3-ol
• Synonyms: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-4'-(2-aminoethyl)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

DATABASE IDS

• CAS Number: 334616-31-8

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: >175°C (dec.)
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A deriviative of Cyclopamine, which demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1

REFERENCES

• Taipale, J., et al.: Nature, 406, 1005 (2000)
• Perron, M., et al.: Development, 130, 1565 (2003)