4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine

• Catalog No.: A603003
• CAS Number: 221244-14-0
• M. F.: C20H21N5
• M. W.: 331.41424
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• IUPAC Traditional name: 1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
• Synonyms: 1-NM-PP1; 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

DATABASE IDS

• CAS Number: 221244-14-0

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 175-176°C
• Solubility: Dichloromethane
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.

REFERENCES

• Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999)
• Davies, S., et al.: Biochem. J., 351, 95 (1999)
• Regan, J., et al.: J. Med. Chem., 45, 2994 (1999)
• Bain, J., et al.: Biochem. J., 371, 199 (1999)
• Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (200