4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine

• Catalog No.: A602985
• CAS Number: 956025-99-3
• M. F.: C16H18BrN5
• M. W.: 360.25162

SYNONYMS

• IUPAC name: 3-[(3-bromophenyl)methyl]-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• IUPAC Traditional name: 3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
• Synonyms: 3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-BrB-PP1

DATABASE IDS

• CAS Number: 956025-99-3

DETAILS

Description (English)

4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival.

REFERENCES

• Eblen, S., et al.: J. Biol. Chem., 278, 14926 (2003)
• Lindsley, C., et al.: Bioorg. Med. Chem. Lett., 15, 761 (2003)
• Manning, B., et al.: Cell, 129, 1261 (2003)
• Heerding, D., et al.: J. Med. Chem., 51, 5663 (2003)