4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine

• Catalog No.: A602980
• CAS Number: 172889-26-8
• M. F.: C16H19N5
• M. W.: 281.35556
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• IUPAC Traditional name: 1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
• Synonyms: PP1; AGL 1872; 1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

DATABASE IDS

• CAS Number: 172889-26-8

PROPERTIES

• Apperance: Off-White to Grey Solid
• Melting Point: 205-207°C
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.

REFERENCES

• Alessi, D., et al.: J. Biol. Chem., 270, 27489 (1995)
• Regan, J., et al.: J. Med. Chem., 45, 2994 (1995)
• Bain, J., et al.: Biochem. J., 2003, 371, 199 (1995)
• Bhat, R., et al.: J. Biol. Chem., 278, 45937 (1995)
• Wilhelm, S., et al.: Cancer Res., 64, 7099