AM 404-d4

• Catalog No.: A575812
• M. F.: C26H37NO2
• M. W.: 395.57748
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (5Z,8Z,11Z,14Z)-N-[4-hydroxy(^2H₄)phenyl]icosa-5,8,11,14-tetraenamide
• IUPAC Traditional name: (5Z,8Z,11Z,14Z)-N-[4-hydroxy(^2H₄)phenyl]icosa-5,8,11,14-tetraenamide
• Synonyms: (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl-d4)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl-d4)-5,8,11,14-eicosatetraenamide

PROPERTIES

• Melting Point: 48-50°C
• Solubility: DMSO
• Solubility: Methanol
• Apperance: Pink Solid
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

It is a labelled metabolite of the well-known analgesic Paracetamol. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.

REFERENCES

• Basile, S., et al.: Pain, 52, 217 (1993)
• Beltramo, M., et al.: Science, 277, 1094 (1993)
• Bisogno, T., et al.: J. Biol. Chem., 272, 3315 (1993)
• Nicholson, R., et al.: Brain Res., 978, 194 (1993)
• La Rana, G., et al.: J. Pharmacol. Exp. Ther., 317, 1365