AM 404

• Catalog No.: A575810
• CAS Number: 183718-77-6
• M. F.: C26H37NO2
• M. W.: 395.57748

SYNONYMS

• IUPAC name: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• IUPAC Traditional name: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• Synonyms: (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide

DATABASE IDS

• CAS Number: 183718-77-6

DETAILS

Description (English)

It is a metabolite of the well-known analgesic Paracetamol. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.

REFERENCES

• Basile, S., et al.: Pain, 52, 217 (1993)
• Beltramo, M., et al.: Science, 277, 1094 (1993)
• Bisogno, T., et al.: J. Biol. Chem., 272, 3315 (1993)
• Nicholson, R., et al.: Brain Res., 978, 194 (1993)
• La Rana, G., et al.: J. Pharmacol. Exp. Ther., 317, 1365