Aloisine A RP107

• Catalog No.: A575450
• CAS Number: 496864-16-5
• M. F.: C16H17N3O
• M. W.: 267.32568
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• IUPAC Traditional name: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• Synonyms: RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol

DATABASE IDS

• CAS Number: 496864-16-5

PROPERTIES

• Apperance: Yellow solid
• Melting Point: 281-283°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

REFERENCES

• Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003)
• Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2003)
• Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2003)