7-Allyl-7,8-dihydro-8-oxoguanosine(Loxoribine)

• Catalog No.: A550000
• CAS Number: 121288-39-9
• M. F.: C13H17N5O6
• M. W.: 339.30398
• Storage: Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 2-amino-9-[(2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-(prop-2-en-1-yl)-6,7,8,9-tetrahydro-1H-purine-6,8-dione
• IUPAC Traditional name: 2-amino-9-[(2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-(prop-2-en-1-yl)-1H-purine-6,8-dione
• Synonyms: 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione, Loxoribine

DATABASE IDS

• CAS Number: 121288-39-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 227-230°C
• Solubility: DMSO
• Storage Condition: Refrigerator, Under Inert Atmosphere

DETAILS

Description (English)

7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine) is a small-molecule immunostimulant. Loxoribine is a toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Loxoribine displays antitumor and antiviral activi

REFERENCES

• Goodman, M.G., et al.: J. Immunol., 135, 3284 (1985)
• Reitz, A. B., et al.: J. Med. Chem., 37, 3561 (1994)