17-(Allylamino-d5) Geldanamycin

• Catalog No.: A549652
• M. F.: C31H43N3O8
• M. W.: 585.68842
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC Traditional name: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• Synonyms: NSC 330507-d5; 17-(Allylamino-d5)-17-demethoxygeldanamycin; CP 127374-d5; Tanespimycin-d5; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17AAG-d5; KOS 953-d5

PROPERTIES

• Apperance: Dark Purple Solid
• Melting Point: 161-163°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

REFERENCES

• Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995)
• Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (1995)
• Basso, A.D., et al.: Oncogene, 21, 1159 (1995)