17-(Allylamino) Geldanamycin

• Catalog No.: A549650
• CAS Number: 75747-14-7
• M. F.: C36H39FN2O7
• M. W.: 630.7024632
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: prop-2-en-1-yl 4-[5-(4-fluorophenyl)-5-hydroxy-4-phenyl-2-(phenylcarbamoyl)-1-(propan-2-yl)-3,10-dioxa-6-azatricyclo[4.4.0.0^2,^4]decan-9-yl]-3-hydroxybutanoate
• IUPAC Traditional name: prop-2-en-1-yl 4-[5-(4-fluorophenyl)-5-hydroxy-1-isopropyl-4-phenyl-2-(phenylcarbamoyl)-3,10-dioxa-6-azatricyclo[4.4.0.0^2,^4]decan-9-yl]-3-hydroxybutanoate
• Synonyms: 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; NSC 330507; 17-(Allylamino)-17-demethoxygeldanamycin; 17AAG; CP 127374; KOS 953; Tanespimycin; 17-AAG

DATABASE IDS

• CAS Number: 75747-14-7

PROPERTIES

• Apperance: Dark Purple Solid
• Melting Point: >194°C (dec.)
• Solubility: Chloroform
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

REFERENCES

• Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995)
• Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (1995)
• Basso, A.D., et al.: Oncogene, 21, 1159 (1995)