Aliskiren-d6 Hydrochloride

• Catalog No.: A536002
• M. F.: C30H54ClN3O6
• M. W.: 588.21926
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2S,4S,5S,7S)-5-amino-N-[2-carbamoyl-2,2-bis(^2H₃)methylethyl]-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide hydrochloride
• IUPAC Traditional name: (2S,4S,5S,7S)-5-amino-N-[2-carbamoyl-2,2-bis(^2H₃)methylethyl]-4-hydroxy-2-isopropyl-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methylnonanamide hydrochloride
• Synonyms: Tekturna Hydrochloride-d6; CGP 60536-d6; CGP60536B-d6; Rasilez-d6 Hydrochloride; (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide-d6 Hydrochloride; SPP 100-d6

PROPERTIES

• Apperance: Light Tan Solid
• Melting Point: 103-105°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An orally active, labelled synthetic nonpeptide renin inhibitor. Antihypertensive.

REFERENCES

• Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000)
• Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2000)
• Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2000)
• Grandman, A.H., et al.: Circulation, 111, 1012 (2000)