Aliskiren Hemifumarate

• Catalog No.: A536001
• CAS Number: 173334-58-2
• M. F.: C30H53N3O6
• M. W.: 551.75832
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide
• IUPAC Traditional name: aliskiren
• Synonyms: Tekturna Hemifumarate; (αS,γS,δS,zS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide Hemifumarate; SPP 100; CGP 60536; CGP60536B; Rasilez Hemifumarate

DATABASE IDS

• CAS Number: 173334-58-2

PROPERTIES

• Apperance: White Solid
• Melting Point: 96-101°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.

REFERENCES

• Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000)
• Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2000)
• Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2000)
• Grandman, A.H., et al.: Circulation, 111, 1012 (2000)