Ala-Leu-Ala-Leu Daunorubicin Hydrochloride

• Catalog No.: A470300
• CAS Number: 76582-70-2
• M. F.: C45H62ClN5O14
• M. W.: 932.45188

SYNONYMS

• IUPAC name: (2S)-N-[(2S,3S,4S,6R)-6-{[(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]-2-[(2S)-2-[(2S)-2-[(2S)-2-aminopropanamido]-4-methylpentanamido]propanamido]-4-methylpentanamide hydrochloride
• IUPAC Traditional name: (2S)-N-[(2S,3S,4S,6R)-6-{[(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]-2-[(2S)-2-[(2S)-2-[(2S)-2-aminopropanamido]-4-methylpentanamido]propanamido]-4-methylpentanamide hydrochloride
• Synonyms: (8S-cis)-8-Acetyl-10-[[3-[[N-[N-(N-L-alanyl-L-leucyl)-L-alanyl]-L-leucyl]amino]-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Monohydrochloride; Ala-Leu-Ala-Leu-DNR

DATABASE IDS

• CAS Number: 76582-70-2

DETAILS

Description (English)

Daunorubicin linked to proteins shows antitumor activity; prodrug Daunorubicin (D194500) peptide tumor.

REFERENCES

• Ginsburg, G., et al.: J. Biol. Chem., 259, 6667 (1984)
• de Smidt, P., et al.: Cancer Res., 50, 7476 (1984)
• de Smidt, P., et al.: Biochem., 32, 2916 (1984)