S-(5'-Adenosyl)-L-methionine Disulfate Salt (Synthetic)(Mixture of Diastereomers)

• Catalog No.: A291530
• M. F.: C15H23ClN6O5S
• M. W.: 434.89832
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium chloride
• IUPAC Traditional name: SAMe chloride
• Synonyms: S-Adenosyl-L-methionine Disulfate; Active Methionine Disulfate; L-S-Adenosylmethionin Disulfate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Disulfate; 5'-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Disulfate; S-Adenosylmethionine Disulfate; Ademetionine Disulfate

PROPERTIES

• Apperance: Light Beige to Pale Brown Solid
• Melting Point: 121-125°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also

REFERENCES

• Friedel, H., et al.: Drugs, 38, 389 (1989)
• Lu, S., et al.: Int. J. Biochem. Cell Biol., 32, 391 (1989)
• Amin, K., et al.: Pharm. Res., 18, 914 (1989)