N-(5-Adamant-1-yl-methoxy)pentyl Deoxynojirimycin

• Catalog No.: A210000
• CAS Number: 216758-20-2
• M. F.: C22H39NO5
• M. W.: 397.54876

SYNONYMS

• IUPAC name: (3R,4R)-1-[5-(adamantan-1-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
• IUPAC Traditional name: (3R,4R)-1-[5-(adamantan-1-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
• Synonyms: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)pentyl]-3,4,5-piperidinetriol

DATABASE IDS

• CAS Number: 216758-20-2

PROPERTIES

• Apperance: Off White Foam
• Solubility: Ethanol
• Solubility: Methanol

DETAILS

Description (English)

A powerful inhibitor of the non-lysomal glucoceramidase at nanomolar concentrations. At these low concentrations, the lysosomal glucocerebrosidase and a-glucosidase, the glucoceramide synthetase, and the N-linked glycantrimming a-glucosidases of the endop

REFERENCES

• Jeckel, D., et al.: J. Cell Biol., 117, 259 (1992)
• Kato, A., et al.: J. Med. Chem., 48, 2036 (1992)
• Sakabe, K., et al.: J. Biol. Chem., 285, 34460 (1992)