Aconitine

• Catalog No.: A189875
• CAS Number: 302-27-2
• M. F.: C34H47NO11
• M. W.: 645.73708
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (2R,3R,4R,5R,6R,7S,8S,9R,10R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^2,^5.0^1,^1^0.0^3,^8.0^1^3,^1^7]nonadecan-4-yl benzoate
• IUPAC Traditional name: (2R,3R,4R,5R,6R,7S,8S,9R,10R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^2,^5.0^1,^1^0.0^3,^8.0^1^3,^1^7]nonadecan-4-yl benzoate
• Synonyms: (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-Acetate 14-Benzoate

DATABASE IDS

• CAS Number: 302-27-2

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 196-198°C (dec.)
• Solubility: Chloroform
• Solubility: Ethy Acetate
• Storage Condition: Refrigerator

DETAILS

Description (English)

Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular jun

REFERENCES

• Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010)
• Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010)