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(-)-Actinonin

Catalog No. A192000 Name Toronto Research Chemicals
CAS Number 13434-13-4 Website http://www.trc-canada.com
M. F. C19H35N3O5 Telephone +1 (416) 665-9696
M. W. 385.4983 Fax +1 (416) 665-4439
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Storage Chembase ID: 3914

SYNONYMS

IUPAC name
(2R)-N-hydroxy-N'-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
IUPAC Traditional name
actinonin
Synonyms
Actinonin
Actinonine
(2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide
Ro 06-1467
3-[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic Acid
CONA 57

DATABASE IDS

CAS Number 13434-13-4

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Solid
Melting Point 137-139°C
Solubility DMSO
Solubility Methanol
MSDS Link Download

DETAILS

Description (English)
(-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell

REFERENCES

  • Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985)
  • Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (1985)
  • Berg, A., et al.: Biochem., 48, 1584 (1985)
  • Kuehlmann, U., et al.: Life Sci., 84, 1 (1985)