(-)-α-Acetylmethadol-d3 Hydrochloride

• Catalog No.: A186327
• M. F.: C23H32ClNO2
• M. W.: 389.95868

SYNONYMS

• IUPAC name: (3S,6S)-6-(dimethylamino)-4,4-diphenyl(1,1,1-^2H₃)heptan-3-yl acetate hydrochloride
• IUPAC Traditional name: (3S,6S)-6-(dimethylamino)-4,4-diphenyl(1,1,1-^2H₃)heptan-3-yl acetate hydrochloride
• Synonyms: Levacetylmethadol-d3 Hydrochloride; Levomethadyl-d3 Hydrochloride; (-)-α-Acetylmethadol-d3 Hydrochloride; LAAM-d3 Hydrochloride; (3S,6S)-(-)- 6-(Dimethylamino)-4,4-diphenyl-3-heptanol Acetate (Ester)-d3 Hydrochloride; (αS)-β-[(2S)-2-(Dimethylamino)propyl]-α-ethyl-β-phenylbenzeneethanol Acetate (Ester)-d3 Hydrochloride; (-)-6-(Dimethylamino)-4,4-diphenyl-3-heptanol Acetate (Ester)-d3 Hydrochloride; Levo-α-acetylmethadol-d3 Hydrochloride; Levomethadyl Acetate-d3 Hydrochloride; l-α-Acetylmethadol-d3 Hydrochloride; α-(-)-Acetylmethadol-d3 Hydrochloride

DETAILS

Description (English)

A labelled synthetic opioid similar in structure to Methadone (M225865) used in the treatment of opiate dependence. It acts as a μ-opioid receptor agonist. It also acts as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist.

REFERENCES

• Billings, R.E. et al.: Life Sci., 14, 1437 (1974)
• Galici, R. et al.: Pharmacol. Biochem. Behav., 81, 626 (1974)
• Xiao, Y. et al.: J. Pharmacol. Exp. Therap., 299, 366 (1974)