3-O-Acetyl Ezetimibe-d4 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester

• Catalog No.: A173802
• M. F.: C39H39F2NO13
• M. W.: 767.7226664

SYNONYMS

• IUPAC name: methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-{4-[(2S,3R)-3-[(3R)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-[4-fluoro(^2H₄)phenyl]-4-oxoazetidin-2-yl]phenoxy}oxane-2-carboxylate
• IUPAC Traditional name: methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-{4-[(2S,3R)-3-[(3R)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-[4-fluoro(^2H₄)phenyl]-4-oxoazetidin-2-yl]phenoxy}oxane-2-carboxylate
• Synonyms: 4-[(2S,3R)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl-d4)-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate

PROPERTIES

• Apperance: White Solid
• Solubility: Dichloromethane

DETAILS

Description (English)

Labelled intermediate in the preparation of Phase-II metabolites of Ezetimibe. Glucuronide azetidinone cholesterol absorption inhibitor.

REFERENCES

• Mutlib, A., et al.: Drug Metab. Dispos., 20, 451 (1992)
• Clader, J., et al.: J. Med. Chem., 39, 3684 (1992)
• van Heek, M., et al.: J. Pharmacol. Exp. Ther., 283, 157 (1992)