ABT 737

• Catalog No.: A112550
• CAS Number: 852808-04-9
• M. F.: C42H45ClN6O5S2
• M. W.: 813.4269
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonyl)benzamide
• IUPAC Traditional name: 4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonyl)benzamide
• Synonyms: 4-[4-[(4’-Chloro[1,1’-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

DATABASE IDS

• CAS Number: 852808-04-9

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 152-154°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines.

REFERENCES

• Ikegaki, N., et al.: Cancer Res., 54, 6 (1994)
• Kaiser, U., et al.: Lung Cancer, 15, 31 (1994)
• Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (1994)
• Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007)