ABT 263-d8

• Catalog No.: A112502
• M. F.: C47H55ClF3N5O6S3
• M. W.: 974.6127096
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-[(^2H₈)morpholin-4-yl]-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
• IUPAC Traditional name: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-[(^2H₈)morpholin-4-yl]-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
• Synonyms: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide-d8

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 102-107°C
• Solubility: Chloroform
• Solubility: DMSO
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.

REFERENCES

• Adams, J., et al.: Science, 281, 1322 (1998)
• Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (1998)
• Kitada, S., et al.: J. Med. Chem., 46, 4259 (1998)
• Danial, N., et al.: Clin. Cancer Res., 13, 7254 (1998)