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ABT 263_Molecular_structure_CAS_923564-51-6)
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ABT 263

Catalog No. A112500 Name Toronto Research Chemicals
CAS Number 923564-51-6 Website http://www.trc-canada.com
M. F. C47H55ClF3N5O6S3 Telephone +1 (416) 665-9696
M. W. 974.6127096 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer, Under Inert Atmosphere Chembase ID: 72451

SYNONYMS

IUPAC name
4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
IUPAC Traditional name
4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
Synonyms
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide

DATABASE IDS

CAS Number 923564-51-6

PROPERTIES

Certificate of Analysis Download
Apperance Pale Yellow Solid
Melting Point 114-116°C
Solubility Chloroform
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.

REFERENCES

  • Adams, J., et al.: Science, 281, 1322 (1998)
  • Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (1998)
  • Kitada, S., et al.: J. Med. Chem., 46, 4259 (1998)
  • Danial, N., et al.: Clin. Cancer Res., 13, 7254 (1998)