Abiraterone-d4

• Catalog No.: A108492
• M. F.: C24H31NO
• M. W.: 349.50904
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-[(^2H₄)pyridin-3-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-7,13-dien-5-ol
• IUPAC Traditional name: (1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-[(^2H₄)pyridin-3-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-7,13-dien-5-ol
• Synonyms: (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol-d4; CB 7598-d4

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 213-215°C
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

Labelled Abiraterone (A108490). A steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.

REFERENCES

• Denis, L., et al.: Cancer, 72, 3888 (1993)
• Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1993)
• Denmeade, S., et al.: Nat. Rev., 2, 389(1993)
• Scher, H., et al.: J. Clin. Oncol., 23, 8253 (1993)