Cycloheximide

• Catalog No.: PS1002
• CAS Number: 66-81-9
• M. F.: C15H23NO4
• M. W.: 281.34742

SYNONYMS

• Title: 放线菌酮
• IUPAC name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
• IUPAC Traditional name: kaken
• Synonyms: 奈良霉素 A; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; 3-[2-(3,5-二甲基-2-氧代环己基)-2-羟乙基]戊二酰亚胺; 戊二酰亚胺环己酮; Actidione; Naramycin A

DATABASE IDS

• EC Number: 200-636-0
• CAS Number: 66-81-9
• Beilstein Number: 88868
• MDL Number: MFCD00082346

PROPERTIES

• Concentration: neat
• Empirical Formula (Hill Notation): C15H23NO4
• Grade: analytical standard
• Packaging: pkg of 100 mg
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H315-H341-H360D-H411
• European Hazard Symbols: Highly toxic (T+)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P264-P273-P281-P301 + P310-P308 + P313
• RID/ADR: UN 2811 6.1/PG 1
• Risk Statements: 61-28-38-51/53-68
• RTECS: MA4375000
• Safety Statements: 53-45-61
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Description (简体中文)

Biochem/physiol Actions
放线菌酮 (CHX) 是由灰色链霉菌产生的抗生素。它的主要生物活性为真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。CHX 广泛用于选择酵母菌和真菌 CHX 耐药株，可控抑制蛋白合成以检测短寿命蛋白和超高诱导蛋白表达，以及进行凋亡诱导或通过死亡受体促进凋亡诱导。