| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
Brimonidine is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia] |
| Indication |
For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. |
| Pharmacology |
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. |
| Toxicity |
Oral LD50 is 50 mg/kg in mice and 100 mg/kg in rats. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Metabolized primarily by the liver. |
| Absorption |
Minimal systemic absorption occurs after ocular insertion. |
| Half Life |
2 hours |
| Elimination |
It is metabolized primarily by the liver. Urinary excretion is the major route of elimination of the drug and its metabolites. |
| External Links |
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