N-Ethylmaleimide

• Catalog No.: 04260
• CAS Number: 128-53-0
• M. F.: C6H7NO2
• M. W.: 125.12528
• Purity: ≥99.0% (HPLC)

SYNONYMS

• Title: N-乙基马来酰亚胺
• IUPAC name: 1-ethyl-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC Traditional name: N-ethylmaleimide
• Synonyms: NEM

DATABASE IDS

• CAS Number: 128-53-0
• MDL Number: MFCD00005509
• PubChem SID: 24845706
• Beilstein Number: 112448
• EC Number: 204-892-4

PROPERTIES

• Antion Traces: chloride (Cl-): ≤50 mg/kg
• Antion Traces: sulfate (SO42-): ≤100 mg/kg
• Cation Traces: Ca: ≤50 mg/kg
• Cation Traces: Cd: ≤50 mg/kg
• Cation Traces: Co: ≤50 mg/kg
• Cation Traces: Cu: ≤50 mg/kg
• Cation Traces: Fe: ≤50 mg/kg
• Cation Traces: K: ≤100 mg/kg
• Cation Traces: Na: ≤100 mg/kg
• Cation Traces: Ni: ≤50 mg/kg
• Cation Traces: Pb: ≤50 mg/kg
• Cation Traces: Zn: ≤50 mg/kg
• Empirical Formula (Hill Notation): C6H7NO2
• Grade: purum p.a.
• Ignition Residue: ≤0.05%
• Purity: ≥99.0% (HPLC)
• Gene Information: human ... SLC6A3(6531), SLC6A4(6532)
• Boiling Point: 210 °C(lit.)
• Flash Point: 73 °C
• Flash Point: 163.4 °F
• Melting Point: 43-46 °C(lit.)
• Melting Point: 43-46 °C
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H311-H314-H317
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P280-P301 + P310-P305 + P351 + P338-P310
• RID/ADR: UN 2928 6.1/PG 2
• Risk Statements: 21-28-34-43
• RTECS: UX9625000
• Safety Statements: 26-28-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Reagent for the covalent modification of cysteine residues in proteins.
Biochem/physiol Actions
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Description (简体中文)

Application
用于共价修饰蛋白质的半胱氨酸残基的试剂。
Biochem/physiol Actions
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。
增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。