Acetylcholine chloride

• Catalog No.: 03067
• CAS Number: 60-31-1
• M. F.: C7H16ClNO2
• M. W.: 181.66044

SYNONYMS

• Title: 氯化乙酰胆碱
• IUPAC name: [2-(acetyloxy)ethyl]trimethylazanium chloride
• IUPAC Traditional name: acetylcholine chloride
• Synonyms: Acetylcholini chloridum; 氯化乙酰胆碱; ACh

DATABASE IDS

• Beilstein Number: 3571875
• PubChem SID: 24845420
• CAS Number: 60-31-1
• MDL Number: MFCD00011698
• EC Number: 200-468-8

PROPERTIES

• Grade: Ph Eur
• Linear Formula: (CH3)3N+CH2CH2OCOCH3Cl-
• Melting Point: 146-150 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: FZ9800000
• Safety Statements: 26
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Description (简体中文)

Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.