Ethylenediaminetetraacetic acid tetrasodium salt hydrate

• Catalog No.: 03701
• CAS Number: 194491-31-1
• M. F.: C10H14N2Na4O9
• M. W.: 398.18524
• Purity: ≥97.0% (KT)

SYNONYMS

• Title: 乙二胺四乙酸 四钠盐 水合物
• IUPAC name: tetrasodium 2-({2-[bis(carboxylatomethyl)amino]ethyl}(carboxylatomethyl)amino)acetate hydrate
• IUPAC Traditional name: tetrasodium ion(4-) edta hydrate
• Synonyms: EDTA tetrasodium salt; EDTA 四钠盐; 依地酸; 乙二胺四乙酸四钠盐 水合物; Edathamil; Tetrasodium ethylenediaminetetraacetate hydrate

DATABASE IDS

• Beilstein Number: 3861753
• PubChem SID: 24845563
• EC Number: 200-573-9
• MDL Number: MFCD00150025
• CAS Number: 194491-31-1

PROPERTIES

• Linear Formula: (NaOOCCH2)2NCH2CH2N(CH2COONa)2 · xH2O
• Purity: ≥97.0% (KT)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• Safety Statements: 26-39-46
• German water hazard class: 2

DETAILS

Description (English)

Preparation Note
Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.
Application
EDTA is an inhibitor of metalloproteases, at effective concentrations of 1-10 mM. EDTA acts as a chelator of the zinc ion in the active site of metalloproteases, and can also inhibit other metal ion-dependent proteases such as calcium-dependent cysteine proteases. For use as an anticoagulant, disodium or tripotassium salts of EDTA are most commonly used. The optimal concentration is 1.5 mg per ml of blood.

Description (简体中文)

Preparation Note
室温下溶于水的最大浓度可达 1.45M。该溶液的 pH 值约为 10 至 11，而且粘度较大。
Application
EDTA 为金属蛋白酶抑制剂，有效浓度为 1-10 mM。EDTA 可用作金属蛋白酶活性中心锌离子的螯合剂，并且还可抑制其他依赖金属离子的蛋白酶，例如依赖钙的半胱氨酸蛋白酶。作为抗凝血剂时，通常使用 EDTA 的二钠或三钾盐。最佳浓度为每 mL 血液 1.5mg。