Paclitaxel

• Catalog No.: 86346
• CAS Number: 33069-62-4
• M. F.: C47H51NO14
• M. W.: 853.90614
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: taxol

DATABASE IDS

• MDL Number: MFCD00869953
• CAS Number: 33069-62-4
• Beilstein Number: 1420457

PROPERTIES

• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 37/38-41-42/43-62-68
• RTECS: DA8340700
• Safety Statements: 22-26-36/37/39-45
• Storage Temperature: -20°C
• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H318-H334-H335-H341-H361
• European Hazard Symbols: Harmful (Xn)
• Biological Source: from Taxus brevifolia
• Empirical Formula (Hill Notation): C47H51NO14
• Impurities: ≤4% water
• Purity: ≥95% (HPLC)
• Gene Information: human ... BCL2(596)
• Melting Point: 213 °C (dec.)(lit.)
• Solubility: methanol: soluble50 mg/mL, clear, colorless

DETAILS

Description (English)

Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Description (简体中文)

Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).