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Phosphoramidon disodium salt_Molecular_structure_CAS_119942-99-3)
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Phosphoramidon disodium salt

Catalog No. 83645 Name Sigma Aldrich
CAS Number 119942-99-3 Website http://www.sigmaaldrich.com
M. F. C23H32N3Na2O10P Telephone 1-800-521-8956
M. W. 587.467581 Fax
Purity ≥97.0% (TLC) Email
Storage Chembase ID: 134165

SYNONYMS

IUPAC name
disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-[({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}phosphinato)amino]pentanamido]propanoate
IUPAC Traditional name
disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphinato}amino)pentanamido]propanoate
Synonyms
N-(α-Rhamno-pyranosyl-phos-phono)-L-leucyl-L-tryptophan disodium salt
N-(α-Rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-Leu-Trp disodium salt

DATABASE IDS

MDL Number MFCD00077870
CAS Number 119942-99-3
Beilstein Number 8105669

PROPERTIES

Empirical Formula (Hill Notation) C23H32N3Na2O10P
Impurities ≤6% water
Purity ≥97.0% (TLC)
Solubility acetic acid: soluble20 mg/mL, clear, colorless to light yellow-green
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Application
Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase.1 Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.2
Other Notes
Naturally occurring thermolysin inhibitor3; Mode of binding4
Description (简体中文)
Application
Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase.1 Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.2
Other Notes
Naturally occurring thermolysin inhibitor3; Mode of binding4

REFERENCES