Phosphoramidon disodium salt_Molecular_structure_CAS_119942-99-3)

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Phosphoramidon disodium salt
Catalog No.	83645	Name	Sigma Aldrich
CAS Number	119942-99-3	Website	http://www.sigmaaldrich.com
M. F.	C23H32N3Na2O10P	Telephone	1-800-521-8956
M. W.	587.467581	Fax
Purity	≥97.0% (TLC)	Email
Storage		Chembase ID: 134165

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SYNONYMS

IUPAC name

disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-[({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}phosphinato)amino]pentanamido]propanoate

IUPAC Traditional name

disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphinato}amino)pentanamido]propanoate

Synonyms

N-(α-Rhamno-pyranosyl-phos-phono)-L-leucyl-L-tryptophan disodium salt

N-(α-Rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-Leu-Trp disodium salt

DATABASE IDS

MDL Number	MFCD00077870
CAS Number	119942-99-3
Beilstein Number	8105669

PROPERTIES

Empirical Formula (Hill Notation)	C23H32N3Na2O10P
Impurities	≤6% water
Purity	≥97.0% (TLC)
Solubility	acetic acid: soluble20 mg/mL, clear, colorless to light yellow-green
MSDS Link	Download
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature	-20°C
German water hazard class	3

DETAILS

Description (English)

Application
Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase.1 Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.2
Other Notes
Naturally occurring thermolysin inhibitor3; Mode of binding4

Description (简体中文)