Quinine hemisulfate salt monohydrate

• Catalog No.: 22642
• CAS Number: 207671-44-1
• M. F.: C40H54N4O10S
• M. W.: 782.94256

SYNONYMS

• Title: 奎宁 半硫酸盐 一水合物
• IUPAC name: bis((R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol) sulfuric acid dihydrate
• IUPAC Traditional name: bis(quinine) sulfuric acid dihydrate
• Synonyms: 硫酸奎宁; Chinini sulfas; Quinine sulfate (2:1) (salt) dihydrate

DATABASE IDS

• Beilstein Number: 6113937
• CAS Number: 207671-44-1
• MDL Number: MFCD00150790
• PubChem SID: 24853567

PROPERTIES

• Empirical Formula (Hill Notation): C20H24N2O2 · 0.5H2O4S · H2O
• Grade: Ph Eur
• Pharmacopeia: testing & handling conforms to Pharmacopeia
• Melting Point: ~225 °C (dec.)(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• German water hazard class: 3

DETAILS

Description (English)

Application
Used to study the toxicity of heme (FP)-complexes.
Biochem/physiol Actions
Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Description (简体中文)

Application
Used to study the toxicity of heme (FP)-complexes.
Biochem/physiol Actions
钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂；最初从南美树木的金鸡纳科中分离出来的生物碱。