Inosine

• Catalog No.: 57470
• CAS Number: 58-63-9
• M. F.: C10H12N4O5
• M. W.: 268.22608
• Purity: ≥99.0% (HPLC)

SYNONYMS

• IUPAC name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
• IUPAC Traditional name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• Synonyms: Hypoxanthine 9-β-D-ribofuranoside; (-)-Inosine

DATABASE IDS

• Beilstein Number: 624896
• EC Number: 200-390-4
• MDL Number: MFCD00066770
• CAS Number: 58-63-9

PROPERTIES

• Empirical Formula (Hill Notation): C10H12N4O5
• Ignition Residue: ≤0.05%
• Purity: ≥99.0% (HPLC)
• Quality: crystallized
• Melting Point: 222-226 °C (dec.)(lit.)
• Optical Rotation: [α]20/D -76±2°, c = 1% in 0.1 M NaOH
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.

Description (简体中文)

Biochem/physiol Actions
Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.