α-Estradiol

• Catalog No.: 46542
• CAS Number: 57-91-0
• M. F.: C18H24O2
• M. W.: 272.38196

SYNONYMS

• Title: α-雌二醇
• IUPAC name: (1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC Traditional name: estradiol 17 α
• Synonyms: 3,17α-Dihydroxy-1,3,5(10)-estratriene; 雌二醇; 1,3,5(10)-雌甾三烯-3,17α-二醇; 3,17α-二羟基-1,3,5(10)-雌三烯; 1,3,5(10)-Estratriene-3,17α-diol; Epiestradiol

DATABASE IDS

• PubChem SID: 24870273
• MDL Number: MFCD00064144
• CAS Number: 57-91-0
• EC Number: 200-354-8

PROPERTIES

• Empirical Formula (Hill Notation): C18H24O2
• Grade: VETRANAL™, analytical standard
• GHS Signal Word: Warning
• GHS Hazard statements: H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P281
• Risk Statements: 40
• RTECS: KG3750000
• Safety Statements: 22-24/25
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Legal Information
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Description (简体中文)

Biochem/physiol Actions
雌二醇（称为 α-雌甾二醇或 17α-雌二醇）为人类乳腺癌细胞组织培养中的生物活性雌激素。17-雌二醇及其选择性受体 (ER-X) 不是传统激素/受体内分泌系统的一部分，而是在成人大脑生长中具有重要自分泌/旁分泌功能的系统的一部分。在更年期以及神经退化性疾病（例如阿尔茨海默氏病和缺血性中风）的治疗中，17-雌二醇可能对激素替代物疗法具有重要意义。
法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC