Guanosine 3′,5′-cyclic monophosphate sodium salt

• Catalog No.: 51055
• CAS Number: 40732-48-7
• M. F.: C10H11N5NaO7P
• M. W.: 367.187171
• Purity: ≥99.0% (HPLC)

SYNONYMS

• IUPAC name: sodium (4aR,6R,7R,7aS)-6-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC Traditional name: sodium 3',5'-cyclic gmp anion
• Synonyms: 3′,5′-cGMP-Na; Guanosine 3′,5′-cyclophosphate monosodium salt; cGMP; 3′,5′-Cyclic GMP monosodium salt; cyclic GMP

DATABASE IDS

• CAS Number: 40732-48-7
• EC Number: 255-056-0
• Beilstein Number: 6467425
• MDL Number: MFCD00038424

PROPERTIES

• Empirical Formula (Hill Notation): C10H11N5NaO7P
• Purity: ≥99.0% (HPLC)
• Shipped in: wet ice
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Description (简体中文)

Biochem/physiol Actions
An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).