Spermine dihydrate

• Catalog No.: 85588
• CAS Number: 403982-64-9
• M. F.: C10H30N4O2
• M. W.: 238.3708
• Purity: ≥99.5% (GC)

SYNONYMS

• Title: 精胺 二水合物
• IUPAC name: (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine dihydrate
• IUPAC Traditional name: spermine dihydrate
• Synonyms: N,N′-双(3-氨丙基)-1,4-丁二胺; N,N′-Bis(3-aminopropyl)-1,4-diaminobutane; 肌胺; Musculamine; Neuridine; Gerontine; 精素; 肝胺

DATABASE IDS

• Beilstein Number: 7526933
• EC Number: 200-754-2
• MDL Number: MFCD01459904
• CAS Number: 403982-64-9
• PubChem SID: 24888220

PROPERTIES

• Antion Traces: chloride (Cl-): ≤50 mg/kg
• Antion Traces: sulfate (SO42-): ≤50 mg/kg
• Cation Traces: Al: ≤5 mg/kg
• Cation Traces: As: ≤0.1 mg/kg
• Cation Traces: Ba: ≤5 mg/kg
• Cation Traces: Bi: ≤5 mg/kg
• Cation Traces: Ca: ≤10 mg/kg
• Cation Traces: Cd: ≤5 mg/kg
• Cation Traces: Co: ≤5 mg/kg
• Cation Traces: Cr: ≤5 mg/kg
• Cation Traces: Cu: ≤5 mg/kg
• Cation Traces: Fe: ≤5 mg/kg
• Cation Traces: K: ≤50 mg/kg
• Cation Traces: Li: ≤5 mg/kg
• Cation Traces: Mg: ≤5 mg/kg
• Cation Traces: Mn: ≤5 mg/kg
• Cation Traces: Mo: ≤5 mg/kg
• Cation Traces: Na: ≤50 mg/kg
• Cation Traces: Ni: ≤5 mg/kg
• Cation Traces: Pb: ≤5 mg/kg
• Cation Traces: Sr: ≤5 mg/kg
• Cation Traces: Zn: ≤5 mg/kg
• Impurities: insoluble matter, passes filter test
• λ: 1 M in H2O
• Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2 · 2H2O
• Product Line: BioUltra
• Purity: ≥99.5% (GC)
• Gene Information: human ... GRIN2B(2904)rat ... Grin2a(24409)
• Absorption Wavelength: λ: 260 nm Amax: 0.20
• Absorption Wavelength: λ: 280 nm Amax: 0.20
• Melting Point: 63-64 °C
• pH: 12.0-13.5 (25 °C, 1 M in H2O)
• Solubility: H2O: soluble1 M at 20 °C, clear, colorless
• GHS Signal Word: Danger
• GHS Hazard statements: H314
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P280-P305 + P351 + P338-P310
• RID/ADR: UN 3259 8/PG 2
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 8
• UN Number: 3259
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Polyamines: Review1; Inhibitor of ATPase2,3; DNA polymerase4; ribonuclease5
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Description (简体中文)

Other Notes
聚胺：综述1；ATP 酶抑制剂2,3；DNA 聚合酶4；核糖核酸酶5
Biochem/physiol Actions
多胺位点混合型 NMDA 激动-拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。